A forum dedicated to the expansion in neuropathology knowledge for students and practitioners alike.
This video is part of a multi-part series reviewing new changes incorporated into the new 5th edition of the WHO classification of tumors of the central nervous system. This video utilizes a case-based format to review important changes in the classification of ependymomas. https://youtu.be/lMVTvFrisbw
Ependymomas are tumors that arise from specialized glia called ependymal cells, which line the central cerebral spinal fluid (CSF) containing spaces within the brain and spinal cord called the ventricles and central canal, respectively. When ependymomas occur in the spinal cord, their central location requires that the surgeon cut through the spinal cord in order... Continue Reading →
The microscopic appearance of ependymomas is dominated by the presence of radially-arranged tumor cells forming rosettes (black arrows), which are named for their resemblance to the flower-like architecture of rose windows in gothic cathedrals. The perivascular pseudorosette, characterized by tumor cells radially arranged around a central vessel, is more common by far, but it is not specific to... Continue Reading →
Ependymal tumors are the third most common primary spinal tumor in adults, after meningiomas and peripheral nerve sheath tumors. WHO (World Health Organization) Grade II spinal ependymomas, like the one depicted on this sagittal MRI of the cervical spine, have a typical radiographical appearance featuring an intramedullary oval-shaped mass with contrast enhancement. Ependymomas are often... Continue Reading →
Ependymomas are glial tumors that commonly harbor perivascular pseudo-rosettes, seen here, characterized by radially arranged tumor cells around a blood vessel core. https://youtu.be/UXDIYV_yMro
A common histologic finding in ependymomas (shown here) are perivascular pseudo-rosettes characterized by neoplastic ependymal cell nuclei radiating outward from a blood vessel, which creates a pink zone of glial processes immediately surrounding the blood vessels.
Adventures in Neuropathology 