A forum dedicated to the expansion in neuropathology knowledge for students and practitioners alike.
HIV-induced compromise of the immune system leaves afflicted persons vulnerable to a wide variety of infections. In this video, we discuss the neuroradiology and pathologic findings of an HIV+ patient with a brain infection caused by the protozoan parasite: Toxoplasma gondii. https://youtu.be/9mBmgNLz13o
Part 3 of a three-part series reviewing the effects of radiation on the brain. Join in on this grand finale as we review brain tumor development in a pilot who had logged many hours flying aircraft at high altitudes. High altitude pilots at the edge of the Earth's protective atmospheric shield, and astronauts just beyond it,... Continue Reading →
Part 2 of a three-part series reviewing the effects of radiation on the brain. Radiation is commonly used to treat a wide variety of neoplastic conditions and often has great success, but sometimes the treatment can cause additional problems. Join me on a narrated tour of radiation’s dark side in this review of radiation-induced brain... Continue Reading →
Part 1 of a three-part series reviewing the effects of radiation on the brain. Radiation is commonly used to treat a wide variety of neoplastic conditions and often has great success, but sometimes the treatment can cause additional problems. Join me on a narrated tour of radiation’s dark side in this review of radiation necrosis... Continue Reading →
COVID-19 autopsy case: a clinicopathologic report and narrated review of lung, heart, and other autopsy pathology findings in a previously healthy woman, including discussion of discordant cardiac findings in this patient with clinical suspicion of viral myocarditis. https://youtu.be/LV7SFxapsRE
Join me for a narrated pathology review of breast cancer (ductal adenocarcinoma) metastatic to brain. https://youtu.be/EkRq-Vs5WoU
Take an anatomy tour through a coronal section of the normal brain at the level of the anterior commisure. Join me as I review the major neuroanatomical structures of the normal brain, touching on structures that are important to normal functioning and also key players in certain disease processes. https://youtu.be/lwF0AySb0c0
Ependymomas are tumors that arise from specialized glia called ependymal cells, which line the central cerebral spinal fluid (CSF) containing spaces within the brain and spinal cord called the ventricles and central canal, respectively. When ependymomas occur in the spinal cord, their central location requires that the surgeon cut through the spinal cord in order... Continue Reading →
On gross examination, hemangioblastoma characteristically exhibits a yellow to yellow-orange color (similar to that of adipose tissue) due to the presence of lipid within the cytoplasm of neoplastic cells. On microscopic examination, the cells appear clear because the lipid that once filled the cytoplasm was washed out during tissue processing. Hemangioblastoma usually arises within the... Continue Reading →
The pineal gland is a midline structure involved in the regulation of circadian rhythm. The "internal clock" that allows for coordination of sleep and wake cycles with changes in night and day is largely regulated by the actions of melatonin, a neurotransmitter that is produced by the constituent cell of the pineal gland: the pinealocyte. Pinealocytes give rise to a rare group of tumors... Continue Reading →
