During the first half of gestation, the human fetal brain has a smooth surface. At about 20 weeks gestation, the brain begins to form the bumps (gyri) and grooves (sulci) that are typical of the adult brain, averaging about 1 sulcus per week of gestation after 20 weeks. The brain of this 25 week gestation... Continue Reading →
Video: TORCH Infections – An autopsy review of a premature fetus with an intrauterine Herpes Simplex Virus.
This case presents just one of many reasons why prenatal care is so important for prevention, detection, and treatment of devastating intrauterine infections. This video includes review of the microscopic appearance of the Herpes-infected brain and macroscopic findings of affected visceral organs. https://youtu.be/L7eHnEB9iDM
Dandy-Walker malformation, an uncommon brain abnormality that may be seen in isolation or in association with other congenital abnormalities of brain development, is characterized by an enlarged posterior fossa, agenesis or hypoplasia of the cerebellar vermis, and cystic dilatation of the fourth ventricle. In this case of a term infant with multiple congenital abnormalities, the superior most aspect of the... Continue Reading →
Premature Fetal Brain
The brain of a premature fetus, shown here (front of brain pointing to the left) is initially smooth in the early stages of development. After about 20 weeks gestation, grooves develop in the cortical surface that gradually become more defined until they form well delineated gyri and sulci (i.e. bumps and grooves) typical of a mature brain. The brain... Continue Reading →
Video: Bacterial ventriculitis in prematurity.
https://youtu.be/qi41D2AgzCg Learn about bacterial infections in the ventricle of a fetus.