Tripolar Atypical Mitosis in Glioblastoma

Cell division occurs in four major stages (prophase, metaphase, anaphase, and telophase) during which DNA duplicates itself and condenses, chromosomes centrally align and are pulled apart by two centrosomes on either side of the cell, and the cytoplasm separates to form two separate daughter cells. Cancer cells are able to enter into cell division by bypassing the usual complex ballet of cell... Continue Reading →

Atypical Meningioma – Mitoses and Macronucleoli

The vast majority of meningiomas are benign grade I tumors.  Meningiomas can be upgraded to grade II, called atypical meningiomas, if they show increased mitotic activity (4 or more mitoses in 10 high power fields) or other worrisome histopathologic features, such as tumor cells exhibiting a prominent and large nucleolus.  Notice the mitosis in the center-right of the image and... Continue Reading →

Glioblastomas

Glioblastomas are high grade astrocytomas that often exhibit microvascular proliferation, characterized by atypical hypertrophic and hyperplastic endothelial cells. A mitotic figure within a proliferating endothelial cell is present in the top right corner of the image.

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