Schwannoma Gross Appearance

Peripheral nerve fibers are sheathed by Schwann cells, which occasionally give rise to a Schwannoma (also termed neurilemoma), a circumscribed tumor that typically occurs along the peripheral aspect of a nerve.  Unlike neurofibromas, schwannomas often can be excised without sacrificing the parent nerve, leaving the patient functionally intact.  Depending on the degree of microscopic microcystic changes, schwannomas can have a soft... Continue Reading →

Pilocytic Astrocytoma – Molecular testing to aid histologic diagnosis.

Pilocytic Astrocytoma (PA) characteristically exhibits biphasic morphology featuring densely fibrillar, compact regions alternating with loosely-cohesive microcystic or myxoid areas; the latter is pictured here.  Diagnosis can be difficult, especially on small biopsies, but molecular testing can help.  BRAF-KIAA1549 fusion occurs in about 70% of PAs, whereas BRAF V600E mutation occurs in about 5-10% of PAs. 

Pilocytic Astrocytoma Cytology

Pilocytic astrocytoma is a circumscribed glioma (WHO Grade I) commonly found in children and young adults. Characteristic features include piloid cells with long, thin, hair-like cytoplasmic processes and a myxoid background, which are both seen here in this medium power image of a cytologic smear preparation performed during intraoperative consultation.  

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