Substantia Nigra decreased pigmentation in Parkinson Disease

The substantia nigra (literal translation: “black substance”) is a portion of the midbrain that contains pigmented dopamine-producing neurons.  Degeneration of these cells causes relative depigmentation the substantia nigra, representing a finding that is typical of Parkinson Disease, but may also be present in other neurodegenerative disorders such as Alzheimer Disease. Shown here is the basal... Continue Reading →

Lewy Body

Parkinson’s Disease is a neurodegenerative disease associated with the presence of abnormal pink-purple inclusions, called Lewy bodies, which contain alpha-synuclein protein and are commonly found in pigmented neurons (shown here).

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