A forum dedicated to the expansion in neuropathology knowledge for students and practitioners alike.
This video is part of a multi-part series reviewing new changes incorporated into the new 5th edition of the WHO classification of tumors of the central nervous system. This video utilizes a case-based format to review important changes in the classification of ependymomas. https://youtu.be/lMVTvFrisbw
This video is part of a multi-part series reviewing new changes incorporated into the new 5th edition of the WHO classification of tumors of the central nervous system. This video utilizes a case-based format to review important changes in the classification of IDH-mutant and IDH-wildtype diffuse gliomas. https://youtu.be/cfPaeNb04Z8
This video is part of a multi-part series reviewing new changes incorporated into the new 5th edition of the WHO classification of tumors of the central nervous system. This video utilizes a case-based format to review important changes in the classification of IDH-mutant and IDH-wildtype diffuse gliomas. https://youtu.be/rskXkeY6DN0
Part 3 of a three-part series reviewing the effects of radiation on the brain. Join in on this grand finale as we review brain tumor development in a pilot who had logged many hours flying aircraft at high altitudes. High altitude pilots at the edge of the Earth's protective atmospheric shield, and astronauts just beyond it,... Continue Reading →
Part 2 of a three-part series reviewing the effects of radiation on the brain. Radiation is commonly used to treat a wide variety of neoplastic conditions and often has great success, but sometimes the treatment can cause additional problems. Join me on a narrated tour of radiation’s dark side in this review of radiation-induced brain... Continue Reading →
The cerebral hemispheres are supplied with blood via three major arteries: the anterior, middle, and posterior cerebral arteries. This coronal section through the frontal lobes shows hemorrhage involving the vascular territory of which of these three major cerebral arteries? Answer: The cerebral hemispheres are supplied with blood via three major arteries: the anterior, middle, and posterior... Continue Reading →
Cranial nerve schwannomas most commonly arise from Schwann cells that myelinate the distal aspect of the vestibular division of the 8th cranial nerve. Vestibular schwannomas, sometimes referred to by the double misnomer "acoustic neuroma" (it is a double misnomer because they are not neuromas and they do not usually involve the acoustic division of cranial... Continue Reading →
For many years the only mechanism for observing gross pathologic features of CNS neoplasms was to examine brains extracted after death. However, advancements in imaging technology now allow providers to observe typical gross neuropathological findings in the brains of living patients. Some brain tumors have characteristic MRI findings, an example of which is a cyst... Continue Reading →
Schwannomas are peripheral nerve sheath tumors that arise from cells that myelinate peripheral nerve axons called Schwann cells. A classic histologic finding in schwannomas are Verocay bodies (arrows), which consist of short palisades of tumor cell nuclei separated by eosinophilic anucleate bands of tumor cell processes. Verocay bodies are often more prominent in schwannomas that arise in the setting of a... Continue Reading →
Astrocytomas (i.e. glial tumors that diffusely infiltrate through brain tissue) are composed of neoplastic astrocytes that may occasionally exhibit certain morphologic differences when observed microscopically. Gemistocytic astrocytes are characterized by eccentric nuclei and plump pink cytoplasm that superficially resembles the belly of a pregnant woman when viewed from above. Neoplasms that are predominantly composed of... Continue Reading →
Adventures in Neuropathology 