A forum dedicated to the expansion in neuropathology knowledge for students and practitioners alike.
This cystic and solid suprasellar mass, seen on this brain cut in the coronal plane, represents the classic gross appearance of a craniopharyngioma with typical focal yellow calcifications. The solid parts on gross examination correlate with enhancing regions on MRI while the cystic regions characteristically contain "machine oil"-like fluid, which is not appreciated in this... Continue Reading →
A review of common gross findings of acute traumatic brain injury (TBI), including a discussion of herniation types and contusional patterns. https://www.youtube.com/watch?v=vnPdJ77khgo&t=333s
Psammoma bodies, lamellated purple concretions composed of calcium and other ions, are commonly found in meningiomas and are particularly numerous in the psammomatous variant of meningioma, pictured here. Psammomatous meningiomas are low grade (WHO grade I) tumors that often have a gritty texture on gross evaluation due to increased numbers of psammoma bodies and dystrophic calcification often necessitating... Continue Reading →
Metastatic cancers (i.e. cancers that originate somewhere else and travel to the brain usually via the bloodstream) can occur singly or, as pictured here, as multiple lesions. Sometimes brain metastases represent the initial clue that the person has cancer somewhere else in the body, as was the case for this patient who was found to have three enhancing cerebral lesions... Continue Reading →
Although meningiomas are classically dura-based lesions, they can also arise in the choroid plexus and, thus, must be considered in the differential diagnosis for intraventricular lesions. This intraventricular meningioma, shown here, is growing underneath normal choroid plexus epithelium.
Ependymomas are glial tumors that commonly harbor perivascular pseudo-rosettes, seen here, characterized by radially arranged tumor cells around a blood vessel core. https://youtu.be/UXDIYV_yMro
https://youtu.be/6nYyMnAxn_o Cryptococcal Meningoencephalitis explained.
The brain of a premature fetus, shown here (front of brain pointing to the left) is initially smooth in the early stages of development. After about 20 weeks gestation, grooves develop in the cortical surface that gradually become more defined until they form well delineated gyri and sulci (i.e. bumps and grooves) typical of a mature brain. The brain... Continue Reading →
https://youtu.be/qi41D2AgzCg Learn about bacterial infections in the ventricle of a fetus.
A review of the histopathologic diagnosis of the most common primary malignant brain tumor: glioblastoma. https://www.youtube.com/watch?v=3KD6wnMR6Lg&t=74s
Adventures in Neuropathology 