A forum dedicated to the expansion in neuropathology knowledge for students and practitioners alike.
Hemangioblastoma is highly vascular tumor with neoplastic stromal/interstitial cells that have a variably clear cell appearance due to their lipid and glycogen cytoplasmic contents. Hemangioblastomas can be found in patients with von Hippel Lindau (VHL) syndrome, who also have increased risk of developing renal cell carcinoma (RCC). Immunostains can be used to differentiate the inhibin-positive... Continue Reading →
Review of brain labeled with amyloid immunostain that reveals Cerebral Amyloid Angiopathy and Alzheimer-type amyloid plaques. https://www.youtube.com/watch?v=B7UKd-aSuxQ Subscribe to our YouTube channel for more Neuropathology educational topics: https://www.youtube.com/channel/UCw_0moRmVeFNF5kkVHrAU4g
Basic histopathologic diagnosis of a meningioma that has been embolized. https://www.youtube.com/watch?v=4B0P5xwvsFM
Choroid plexus papillomas are low grade tumors that arise from the intraventricular CSF-producing choroid plexus. Here we see the transition from the round bland nuclei and ample pink cytoplasm of the normal choroid plexus epithelium (bottom of image) to the dysplastic columnar epithelium of the papilloma (top of image) featuring nuclear crowding and mitotic activity... Continue Reading →
Dorsal root ganglia are located along the length of the spinal cord and are composed of clusters of large neuron cell bodies, each with a prominent nucleus and nucleolus, that belong to sensory nerves whose axons deliver sensory information to the spinal cord.
The brain of this premature fetus (cut in coronal section) shows a germinal matrix hemorrhage with associated white matter damage. Notice that the blood also fills the 3rd ventricle. Germinal matrix hemorrhage is the most common cause of intraventricular hemorrhage in fetuses and babies with a gestation age between 23 and 28 weeks. The brain... Continue Reading →
Astrocytes, like the one highlighted here by GFAP stain, are star-shaped glial cells that are involved in a large number of CNS functions, including the blood brain barrier. Together with pericytes and endothelial cells, astrocyte end plates surrounding a vessel forms an essential component of the blood brain barrier which severely limits passage of certain... Continue Reading →
Adventures in Neuropathology 