A normal adult loses about 0.2% of brain volume every year after middle age.  Compared to young and middle-aged adults, the brains of the elderly have comparatively widened sulci, narrowed gyri, a thin cortical ribbon, and enlarged ventricles due to progressive brain volume loss, which, clinically, may contribute slower processing speed for cognitive tasks and other changes.  Microglia-mediated synaptic pruning and other etiologies for decreasing cortical volume in the... Continue Reading →