Globose Neurofibrillary Tangle

Neurodegenerative diseases commonly have abnormal protein inclusions that ultimately contribute to neuron death.  One such example is abnormally hyperphosphorylated tau protein, the major component of neurofibrillary tangles (NFTs), which are a key microscopic feature of Alzheimer Disease and lesser known neurodegenerative diseases, such as Frontotemporal Lobar Degeneration (FTLD).  Like water in a vase, an NFT will assume the shape of the cell in which it arises.  For example, the classic... Continue Reading →

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