Periventricular Leukomalacia (PVL)

Periventricular Leukomalacia (PVL) is a type of brain damage that affects fetuses and premature babies. At this stage of brain  development, the white matter surrounding the ventricles is particularly vulnerable to hypoxic (lack of oxygen) or ischemic (lack of blood flow) injury for a variety of reasons, including high metabolic demand in a location that... Continue Reading →

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Brain Eating Amoeba

Naegleria fowleri, better known as "brain-eating amoeba", is a free-living amoeba that is a major cause of a rare brain infection called Primary Amebic Meningoencephalitis, which typically affects young people with a history of swimming in warm fresh water such as a lake or stream. After entering the nose and crawling up the olfactory nerves... Continue Reading →

Malignant Meningitis

The brain is surrounded by several layers of protective coverings collectively called meninges.  The semi-translucent innermost layers, called the leptomeninges, form a "shrink-wrap" around the brain that allows for easy flow of cerebrospinal fluid (CSF) along the outer surface of central nervous system structures. Unfortunately, it also allows for easy spread of neoplastic cells.  The image shows the inferior aspect... Continue Reading →

Myxopapillary Ependymoma: Radiology-Pathology Correlation

Myxopapillary ependymoma arises in the lumbar region of the spinal cord and typically produces symptoms associated with impingement of the spinal nerve roots of the cauda equina. It usually appears as an oval or sausage-shaped contrast-enhancing mass, like the one pictured in this MRI image (sagittal post-contrast T1 Fat-sat).  The myxopapillary ependymoma in the inset photograph represents a gross surgical... Continue Reading →

Secretory Meningioma: A unique Meningioma variant

The secretory subtype of meningioma (pictured here) is just one of many variants of meningioma, a usually histologically benign tumor that arises from the meninges (i.e. the outer coverings overlying the brain) and often contains concentrically-layered calcifications called psammoma bodies.  The secretory variant can be suspected on imaging by the exuberant edema often seen in the adjacent brain tissue.  Microscopically,... Continue Reading →

True Ependymal Rosettes in Ependymoma

The microscopic appearance of ependymomas is dominated by the presence of radially-arranged tumor cells forming rosettes (black arrows), which are named for their resemblance to the flower-like architecture of rose windows in gothic cathedrals.  The perivascular pseudorosette, characterized by tumor cells radially arranged around a central vessel, is more common by far, but it is not specific to... Continue Reading →

Severe Jaundice of the Brain

Not a trick of the eyes.  This brain with a pronounced green discoloration belonged to an adult with marked jaundice due to acute and severe liver disease. Jaundice occurs when the blood carries higher than normal levels of bilirubin, a substance that is usually processed by the liver into bile which is then eliminated via the stool and urine. Liver disease... Continue Reading →

Multiple Schwannomas in Neurofibromatosis Type II (NF2)

Schwannomas are typically sporadic lesions which stem from the Schwann cells that myelinate (or insulate) the peripheral nerves.  Patients with multiple schwannomas are more likely to have an associated familial tumor syndrome, such as Neurofibromatosis Type II (NF2). NF2 is a disorder in which a person inherits a defective gene, called NF2, that affects the merlin tumor suppressor protein thereby permiting... Continue Reading →

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