Vestibular Schwannomas

Intracranial schwannomas most commonly arise from the vestibular portion of the Vestibulocochlear nerve (cranial nerve VIII). The central/proximal aspect of the nerve is myelinated by oligodendroglial cells whereas the distal/peripheral aspect is myelinated by Schwann cells. These distally located Schwann cells give rise to vestibular schwannomas that originate in the distal aspect of the nerve, usually within the internal auditory canal where it... Continue Reading →

Video: Intraoperative Consultation – Frozen Section

A high level walk-through of the process of a pathological evaluation of a specimen biopsied for an intraoperative consultation, including frozen section preparation. https://youtu.be/XU9zIjQ7Sjw   For further study on this topic and others related to neuropathology and neuroanatomy,  the following books come highly recommended, and a small portion of the proceeds (or any Amazon purchase through these links)... Continue Reading →

Video: Multiple Sclerosis Part II – Frozen Section Diagnosis

Part 2 of a multi-part series on Multiple Sclerosis that reviews the microscopic features and histopathologic diagnosis of a frozen section of brain tissue assessed during intraoperative consultation. https://youtu.be/60Qcjd3Ri38   For further study on this topic and others related to neuropathology and neuroanatomy,  the following books come highly recommended, and a small portion of the proceeds (or any... Continue Reading →

Video: Multiple Sclerosis Part I – Pathogenesis

Part one of a multi-part series dedicated to Multiple Sclerosis:  Pathogenesis. https://youtu.be/iwZ_UmOprN4   For further study on this topic and others related to neuropathology and neuroanatomy,  the following books come highly recommended, and a small portion of the proceeds (or any Amazon purchase through these links) help with expenses of hosting this site:              ... Continue Reading →

Multiple Sclerosis: Macrophages and Granular Mitosis in MS Plaques

Demyelinating lesions, such as those found in multiple sclerosis, typically contain numerous macrophages with abundant myelin debris filling the cytoplasm.  Additionally, atypical and granular mitoses can be seen in demyelinating lesions, though they can also occur in gliomas. Follow us on Facebook, Instagram, and YouTube:  Adventures in Neuropathology

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