Stroke: Resolving Infarction

Brain infarction, or stroke, refers to brain tissue death due to a lack of life-sustaining blood flow to this area.  This brain, which belonged to a person with extensive cardiovascular disease, shows a resolving infarction involving the cerebral cortex of the occipital lobe.  Microscopically this yellow-brown discolored area is infiltrated by an army of macrophages that slowly removes the dead brain tissue until,... Continue Reading →

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Tuberculosis with Caseating Granuloma

Tuberculosis, or TB, is characterized by the formation of granulomas that often have central necrosis, called caseous necrosis due to its cottage-cheese appearance on gross evaluation.  Caseating granulomas characteristically have central necrosis surrounded by an immediate layer of macrophages and inflammatory cells, which, in turn, are surrounded by proliferating fibroblasts.  This effort to contain the... Continue Reading →

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