Multiple Schwannomas in Neurofibromatosis Type II (NF2)

Schwannomas are typically sporadic lesions which stem from the Schwann cells that myelinate (or insulate) the peripheral nerves.  Patients with multiple schwannomas are more likely to have an associated familial tumor syndrome, such as Neurofibromatosis Type II (NF2). NF2 is a disorder in which a person inherits a defective gene, called NF2, that affects the merlin tumor suppressor protein thereby permiting... Continue Reading →

Schwannoma Gross Appearance

Peripheral nerve fibers are sheathed by Schwann cells, which occasionally give rise to a Schwannoma (also termed neurilemoma), a circumscribed tumor that typically occurs along the peripheral aspect of a nerve.  Unlike neurofibromas, schwannomas often can be excised without sacrificing the parent nerve, leaving the patient functionally intact.  Depending on the degree of microscopic microcystic changes, schwannomas can have a soft... Continue Reading →

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