Brain trauma and diffuse axon injury in the Corpus Callosum

Diffuse axonal injury: Trauma that is strong enough to break long slender blood vessels is usually strong enough to break long delicate axons, too.  Therefore, the presence of gross microhemorrhages in long white matter tracts, such as the corpus callosum, strongly suggests that diffuse axonal injury will be seen on microscopic evaluation of the axons comprising these white matter tracts. The image shows... Continue Reading →

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Premature Fetal Brain

The brain of a premature fetus, shown here (front of brain pointing to the left) is initially smooth in the early stages of development.  After about 20 weeks gestation, grooves develop in the cortical surface that gradually become more defined until they form well delineated gyri and sulci (i.e. bumps and grooves) typical of a mature brain.  The brain... Continue Reading →

Ependymoma

A common histologic finding in ependymomas (shown here) are perivascular pseudo-rosettes characterized by neoplastic ependymal cell nuclei radiating outward from a blood vessel, which creates a pink zone of glial processes immediately surrounding the blood vessels. 

Hemangioblastoma

Hemangioblastoma is highly vascular tumor with neoplastic stromal/interstitial cells that have a variably clear cell appearance due to their lipid and glycogen cytoplasmic contents. Hemangioblastomas can be found in patients with von Hippel Lindau (VHL) syndrome, who also have increased risk of developing renal cell carcinoma (RCC). Immunostains can be used to differentiate the inhibin-positive... Continue Reading →

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