https://youtu.be/CHU-464bph8 Review of the histopathologic cancer diagnosis of a carcinoma metastasized to the brain.
Video: Carcinoma Metastasis to Brain
Video: Normal Brain Anatomy and Function – A Lateral View
https://www.youtube.com/watch?v=87BQ0fuQnqI
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Video: Rosenthal Fibers in Pilocytic Astrocytoma
https://youtu.be/SzmLY-yh87U Subscribe to our YouTube channel for more educational Neuropathology, and Neuroanatomy videos:Â Â https://www.youtube.com/channel/UCw_0moRmVeFNF5kkVHrAU4g/videos?
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Glioblastomas
Glioblastomas are high grade astrocytomas that often exhibit microvascular proliferation, characterized by atypical hypertrophic and hyperplastic endothelial cells. A mitotic figure within a proliferating endothelial cell is present in the top right corner of the image.
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Intraparenchymal Hemorrhage
The massive intraparenchymal hemorrhage depicted in the autopsy specimen of a 60-year-old male patient is the result of hypertensive vasculopathy. Bleeding originated in penetrating vessels of the basal ganglia and extended into adjacent cerebral structures. The blood acts as a space-occupying lesion, resulting in uncal and subfalcine herniation with associated tissue destruction.
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Glioblastoma with Ring Enhancement (MRI)
This middle aged patient had a heterogeneous lesion with multiple irregular rings of enhancement following contrast administration. Biopsy revealed glioblastoma with microvascular proliferation and necrosis, both of which contain leaky blood vessels that contribute to contrast enhancement on imaging.
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MRI of Glioblastoma with Subfalcine Herniation
This elderly patient complaining of headache was diagnosed with glioblastoma following biopsy of the heterogeneous, ring-enhancing lesion in the right temporal lobe. Mass effect caused by the space-occupying tumor has pushed the ipsilateral cingulate gyrus under the falx cerebri, resulting in a subfalcine herniation.
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Chordoid Meningioma
The World Health Organization Classification of Tumors of the CNS officially recognizes 13 different variants of meningioma, most of which are Grade 1 tumors that are potentially curable with complete resection. Chordoid meningioma is a rare subtype that accounts for less than 1% of all intracranial meningiomas. They are commonly composed of epithelioid tumor cells,... Continue Reading →
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Glioblastoma with Pseudopalisading Necrosis
Glioblastomas are malignant astrocytomas that often show pseudopalisading necrosis, characterized by palisading of neoplastic cells along the edges of tumor necrosis. Gioblastomas are the most common malignant primary brain tumor.
Adventures in Neuropathology 