A forum dedicated to the expansion in neuropathology knowledge for students and practitioners alike.
Epidermoid cysts (pictured here with surrounding brain tissue) are histologically characterized by a thin layer of squamous epithelium similar to the epidermal lining the skin. However, unlike skin (which sheds its outer layer of dead cells into the environment), the keratin debris of the sloughed-off upper layer of the epidermoid cyst build up within the cyst center resulting in... Continue Reading →
Giant Cell Glioblastoma, also called magnocellular or monstrocellular glioblastoma, is characterized by atypical cells that are extremely large, especially when compared to the non-neoplastic inflammatory cells seen on the left side of the image. The tumor has increased number of dividing cells, including typical mitotic figures (bottom left arrow) and atypical or granular mitoses (bottom... Continue Reading →
Tuberculosis, or TB, is characterized by the formation of granulomas that often have central necrosis, called caseous necrosis due to its cottage-cheese appearance on gross evaluation. Caseating granulomas characteristically have central necrosis surrounded by an immediate layer of macrophages and inflammatory cells, which, in turn, are surrounded by proliferating fibroblasts. This effort to contain the... Continue Reading →
Histopathological diagnosis of Peripheral Neuroblastic Tumors explained (i.e. Neuroblastoma, Ganglioneuroblastoma, and Ganglioneuroma), with an example review of Ganglioneuroma. https://youtu.be/w9FEXK8tvJg
Diffuse axonal injury: Trauma that is strong enough to break long slender blood vessels is usually strong enough to break long delicate axons, too. Therefore, the presence of gross microhemorrhages in long white matter tracts, such as the corpus callosum, strongly suggests that diffuse axonal injury will be seen on microscopic evaluation of the axons comprising these white matter tracts. The image shows... Continue Reading →
Demyelinating lesions, such as those found in multiple sclerosis, typically contain numerous macrophages with abundant myelin debris filling the cytoplasm. Additionally, atypical and granular mitoses can be seen in demyelinating lesions, though they can also occur in gliomas. Follow us on Facebook, Instagram, and YouTube: Adventures in Neuropathology
https://youtu.be/YlKgPHM3YzY Follow us on Facebook, Instagram, and YouTube: Adventures in Neuropathology
https://youtu.be/iQ1Be_0IpJM Follow us on Facebook, Instagram, and YouTube: Adventures in Neuropathology
Hemorrhages and hematomas in the Central Nervous system - A narrative of microscopic features. https://www.youtube.com/watch?v=MCx1DFjANzU&feature=youtu.be Follow us on Facebook, Instagram, and YouTube: Adventures in Neuropathology
Renal cell carcinoma, a relatively common cancer of the kidney, is a highly vascular lesion that will typically bleed extensively during surgery. Just prior to surgery this renal cell carcinoma that had metastasized to the paraspinal soft tissue was embolized using PVA (polyvinyl alcohol), the blue foreign embolic material within the vessel lumen. This process of embolization was... Continue Reading →
Adventures in Neuropathology 